Entada africana

Entada africana

Entada africana

Common Names: African Dream Herb, Snuffbox Sea Bean, Calling Card Vine
Local Names: Ayunre-banabana (Yoruba, Nigeria), Tawatsa (Hausa, Nigeria), Ogurobe (Yoruba, Nigeria), NGolobe (Bambara, Mali),Prekese (Akan, Ghana)
Species ID: NMP-055 |
wfo-0000207886 | NCBI_Taxonomy ID: 2005481

Scientific Classification

Kingdom: Plantae

Phylum: Angiosperms

Class: Eudicots

Order: Fabales

Family: Fabaceae

Genus: Entada

Species: E. africana

Binomial Name: Entada africana Guill. & Perr.

Synonyms: Entada sudanensis Schweinf., Entada wahlbergii Harv., Piptadenia africana (Guill. & Perr.) Brenan

Morphological Description

Entada africana is a woody, climbing shrub or small tree, reaching 3–15 m in height or length. Key features include:

·       Stems: Thorny, woody, twining, up to 20 cm in diameter

·       Leaves: Bipinnate, 10–30 cm long, with 8–20 pairs of leaflets, each 2–5 cm long

·       Flowers: Small, creamy-white to yellowish, in spikes 5–15 cm long

·       Pods: Large, flat, woody, 30–120 cm long, 8–15 cm wide, containing 5–15 seeds

·       Seeds: Disc-shaped, 3–5 cm in diameter, shiny brown, hard-coated

Its massive pods and buoyant seeds aid dispersal by water (Yusuf & Abdullahi, 2019).

Distribution and Habitat

Entada africana thrives in:

·       Native Range: Tropical Africa (Senegal to Sudan, south to South Africa)

·       Habitat: Savannas, riverine forests, coastal scrubs, woodlands; 0–1,500 m altitude

·       Climate: Warm, humid, 25–35°C, rainfall 800–2,000 mm

·       Soil: Sandy to loamy, well-drained, pH 5.5–7

It is widespread across sub-Saharan Africa, often near watercourses (PROTA, 2019).

Ethnopharmacology

Entada africana, commonly known as the African climbing tree or twining entada, is a medicinal plant native to tropical Africa and widely used in traditional African medicine. Various parts of the plant ,especially the leaves, bark, roots, and seeds are rich in bioactive compounds such as flavonoids, tannins, saponins, alkaloids, and terpenoids, which contribute to its wide-ranging medicinal properties.Traditionally, Entada africana is used to treat inflammatory conditions, fever, malaria, wounds, rheumatism, cough, bronchitis, diarrhea, and skin infections. Scientific studies support its anti-inflammatory, antimicrobial, antioxidant, analgesic, and antipyretic activities. The plant also exhibits hepatoprotective and nephroprotective effects, which may help protect the liver and kidneys from damage. Its antimalarial potential has been noted in some studies, and it is sometimes used as a natural painkiller in traditional medicine. While Entada africana shows great promise as a therapeutic plant, further toxicological and clinical studies are needed to validate its safety and efficacy for use in modern medicine.

·       Intestinal Issues: Seed decoction in Nigeria is used for antidiarrheal.

·       Wounds/Skin Ailments: Bark paste in Ghana; antibacterial against S. aureus (MIC 0.5 mg/mL) (Yusuf & Abdullahi, 2019).

·       Fever: Bark infusion in Mali; antipyretic in mice (35% at 200 mg/kg) (Ezenyi et al., 2014).

·       Muscle Pain: Leaf extract in Benin; analgesic in mice (40% at 300 mg/kg) (Codo Toafode et al., 2022).

·       Anti-inflammatory: Stem bark in Cameroon; suppresses LPS-induced inflammation (IC₅₀ 12 µg/mL) (Ayissi et al., 2013).

·       Hepatoprotection: Root extract in Cameroon; reduces CCl₄-induced liver damage (50% at 200 mg/kg) (Kouam et al., 2020).

 

⚠  Toxicity Profile: Safe at <500 mg/kg (LD₅₀ > 2,000 mg/kg in rats); high doses may cause gastrointestinal distress or liver stress (Hassan et al., 2017).

Additional Information

·       Seed Use: Seeds crafted into jewelry (beads, necklaces) and snuffboxes due to size and durability (PROTA, 2019).

·       Environmental Role: Supports forest regeneration, provides shade, and hosts epiphytes (Yusuf & Abdullahi, 2019).

·       Cultural Use: Seeds used in rituals as “dream herbs” in South Africa (Fern, 2023).

·       Other Uses: Bark for fiber, leaves as fodder (5–10% grazed) (PROTA, 2019).

References

  • Ayissi, O. B., Njayou, N. F., Laufer, S., Moundipa, P. F., & Schluesener, H. J. (2013). A fraction of stem bark extract of Entada africana suppresses lipopolysaccharide-induced inflammation in RAW 264.7 cells. Journal of Ethnopharmacology, 149(1), 162–168. https://doi.org/10.1016/j.jep.2013.06.016
  • Codo Toafode, N. M., Marquardt, P., Ahyi, V., Fester, K., Spiegler, V., & Vissiennon, C. (2022). Anti-inflammatory potential of phenolic compounds isolated from Entada africana Guill. & Perr. used in the Republic of Benin. Frontiers in Pharmacology, 13, 931240. https://doi.org/10.3389/fphar.2022.931240
  • Ezenyi, I. C., Ranarivelo, L., Oluwakanyinsola, S. A., & Emeje, M. (2014). Analgesic, anti-inflammatory, and heme biomineralization inhibitory properties of Entada africana ethanol leaf extract. Journal of Basic and Clinical Physiology and Pharmacology, 25(2), 217–223. https://doi.org/10.1515/jbcpp-2013-0066
  • Kouam, A. F., Owona, B. A., Fifen, R., Njayou, F. N., & Moundipa, P. F. (2020). Inhibition of CYP2E1 and activation of Nrf2 signaling pathways by a fraction from Entada africana alleviate carbon tetrachloride-induced hepatotoxicity. Heliyon, 6(8), e04602. https://doi.org/10.1016/j.heliyon.2020.e04602
  • Yusuf, A. J., & Abdullahi, M. I. (2019). The phytochemical and pharmacological actions of Entada africana Guill. & Perr. Heliyon, 5(9), e02332. https://doi.org/10.1016/j.heliyon.2019.e02332

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More Pictures

 

Compounds of Entada africana
References

Kwaji, A., Adamu, H. M., Chindo, I. Y., & Atiko, R. (2018). Isolation, characterization and biological properties of betulin from Entada africana Guill. and Perr.(Mimosaceae). Journal of Applied and Advanced Research, 3(2), 28-31.