tocotrienol
| Compound Structure: |
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| Synonyms: | Tocotrienols; 6829-55-6 ;CCRIS 7711; UNII-0867I0N41V | ||||||||||||||||||||||||||||||||||||||
| Compound ID: | NMPC-1541 | ||||||||||||||||||||||||||||||||||||||
| PubChem ID: | |||||||||||||||||||||||||||||||||||||||
| Molecular Formula: | C26H38O2 | ||||||||||||||||||||||||||||||||||||||
| Canonical SMILES: | CC(=CCCC(=CCCC(=CCCC1(CCC2=C(O1)C=CC(=C2)O)C)C)C)C | ||||||||||||||||||||||||||||||||||||||
| InChIKey: | GJJVAFUKOBZPCB-ZGRPYONQSA-N | ||||||||||||||||||||||||||||||||||||||
| About the compound: | Tocotrienol is any of the four forms, alpha, beta, gamma and delta, of a member of the vitamin E family, with potential hypocholesterolemic, antithrombotic, antioxidant, immunomodulating and antineoplastic activities. Tocotrienol inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, thereby lowering cholesterol levels. In addition, tocotrienol acts through multiple signal transduction pathways to induce cell cycle arrest and caspase-mediated apoptosis, and to decrease tumor cell proliferation. In addition, this agent may inhibit angiogenesis through the blockage of vascular endothelial growth factor receptor (VEGFR) and the subsequent inhibition of tumor cell-induced vessel formation. Also, this agent prevents free radical formation and inhibits lipid peroxidation, thereby preventing DNA cell damage. Tocotrienolfarnesylisoprenoid side chains contain 3 double bonds, which are absent in tocopherols, likely contribute to its anti-cancer activities. |
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| Properties: |
Chemical and Physical Properties
Source:PubChem |
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| Source Species: |
Garcinia kola Lonchocarpus cyanescens |