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Tangeretin, known scientifically as an O-polymethoxylated flavone, is a compound primarily found in tangerine and other citrus peels. It plays a crucial role in strengthening the cell walls of plants, serving as a defensive mechanism against disease-causing pathogens. Additionally, tangeretin has been utilized as a marker compound to identify contamination in citrus juices. Various methods have been employed to extract tangeretin from citrus peels effectively. These methods include:

1. Column chromatography.

2. Preparative-high performance liquid chromatography.

3. Supercritical fluid chromatography.

4. High-speed counter-current chromatography.

5. A combination of vacuum flash silica gel chromatography and flash C8 column chromatography.

6. Flash chromatography.

7. Isolation using ionic liquids followed by a cycle of centrifugation and decantation.

One of the major challenges in using tangeretin in laboratory settings and therapeutic applications is its low solubility, which significantly affects its bioavailability. This low solubility is a common issue with many flavonoids. However, ongoing research and testing of extraction methods aim to maximize efficiency and yield, especially as the potential therapeutic uses of tangeretin in treating cancer and other diseases are becoming more recognized.

Tangeretin is available commercially as a dietary supplement and has shown promise in various pharmaceutical, nutraceutical, and cosmetic applications. The compound is known by several synonyms in scientific literature, including Tangeritin and 5,6,7,8,4’-pentamethoxyflavone (VIII), reflecting its diverse presence and interest in research and industry. The exploration of tangeretin's properties and applications continues to be a significant area of study, particularly in relation to health and disease prevention.

GHS Hazard Statements

H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]

Chemical and Physical Properties

Source:PubChem