1088

Sarcosine, also known as N-methylglycine, or monomethylglycine, is a amino acid with the formula CH3N(H)CH2CO2H. It exists at neutral pH as the zwitterion CH3N+(H)2CH2CO2−, which can be obtained as a white, water-soluble powder. Like some amino acids, sarcosine converts to a cation at low pH and an anion at high pH, with the respective formulas CH3N+(H)2CH2CO2H and CH3N(H)CH2CO2−. Sarcosine is a close relative of glycine, with a secondary amine in place of the primary amine. Sarcosine is ubiquitous in biological materials. It is used in manufacturing biodegradable surfactants and toothpastes as well as in other applications. It is also a reagent in organic synthesis.

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]

• H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]

First Aid

Eyes: Remove any contact lenses, then flush the eyes with water or saline for 20-30 minutes. Avoid applying ointments or other substances without medical advice. Transport the victim to a hospital immediately after flushing, even if there are no symptoms.

Skin: Immediately rinse affected skin with water, removing and isolating all contaminated clothing. Thoroughly wash the skin with soap and water. If symptoms like redness or irritation appear, call a physician and prepare to transport the victim to a hospital.

Inhalation: Exit the contaminated area immediately and breathe fresh air. If symptoms such as wheezing or shortness of breath occur, seek medical assistance and be ready for hospital transport. Use appropriate respiratory protection, such as a Self-Contained Breathing Apparatus (SCBA), if available.

Ingestion: Do not induce vomiting. If the victim is conscious and stable, give water to dilute the chemical and call for medical help immediately. If the victim is convulsing or unconscious, keep the airway clear, position them properly, and transport them to a hospital without delay (NTP, 1992)

National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.

Chemical and Physical Properties

Source: PubChem