949

N,n-dimethylaniline appears as a yellow to brown colored oily liquid with a fishlike odor. Less dense than water and insoluble in water. Flash point 150 °F. Toxic by ingestion, inhalation, and skin absorption. Used to make dyes and as a solvent. N,N-dimethylaniline is a tertiary amine that is aniline in which the amino hydrogens are replaced by two methyl groups. It is a tertiary amine and a dimethylaniline. N,N-Dimethylaniline is used as an intermediate in the manufacture of dyes and other substances. Acute (short-term) inhalation exposure to N,N-dimethylaniline has resulted in effects on the central nervous system (CNS) and circulatory system, with headache, cyanosis, and dizziness in humans. Effects on the blood have been reported in exposed workers. Chronic (long-term) inhalation exposure of animals resulted in effects on the CNS, blood, and liver. No information is available on the reproductive, developmental, or carcinogenic effects of N,N-dimethylaniline in humans. In a National Toxicology Program (NTP) study of rats and mice exposed via gavage, increased incidences of tumors of the spleen and forestomach were observed. EPA has not classified N,N-dimethylaniline for potential carcinogenicity. N,N-Dimethylaniline (DMA) is an organic chemical compound, a substituted derivative of aniline. It consists of a tertiary amine, featuring dimethylamino group attached to a phenyl group. This oily liquid is colourless when pure, but commercial samples are often yellow. It is an important precursor to dyes such as crystal violet.

GHS Hazard Statements

• H301: Toxic if swallowed [Danger Acute toxicity, oral]

• H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

• H331: Toxic if inhaled [Danger Acute toxicity, inhalation]

• H351: Suspected of causing cancer [Warning Carcinogenicity]

• H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

First Aid

1. Eyes:

• Remove any contact lenses.

• Flush eyes with water or saline for 20-30 minutes while contacting medical help.

• Avoid applying any substances to the eyes without a physician's guidance.

• Transport the victim to a hospital immediately, even if there are no apparent symptoms.

2. Skin:

• Immediately rinse the affected skin with water, removing contaminated clothing.

• Wash thoroughly with soap and water.

• Contact medical help immediately, even if no symptoms are apparent.

• Transport the victim to a hospital immediately after washing.

3. Inhalation:

• Leave the contaminated area immediately and breathe fresh air.

• Contact a physician and prepare for hospital transport, even if symptoms aren’t present.

• Rescuers should use proper respiratory protection, ideally a Self-Contained Breathing Apparatus (SCBA).

4. Ingestion:

• Do not induce vomiting.

• If the victim is conscious and not convulsing, give water to dilute the chemical and contact medical help.

• Position convulsing or unconscious victims to keep the airway open and transport immediately to a hospital.

5. Other Considerations:

• Contact a physician for advice on long-term health effects and potential medical monitoring for exposure to carcinogenic chemicals, with recommendations tailored based on the specific chemical and exposure circumstances (NTP, 1992).

National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.

Chemical and Physical Properties

Source: PubChem