Ginsenosides Rg1

Ginsenosides Rg1
Compound Structure:
Synonyms: Ginsenoside RG;1 22427-39-0; Sanchinoside; C1 Panaxoside A ;Ginsenoside A2
Compound ID: NMPC-1080
PubChem ID:

441923

Molecular Formula: C42H72O14
Canonical SMILES: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)OC5C(C(C(C(O5)CO)O)O)O)C)O)C)OC6C(C(C(C(O6)CO)O)O)O)C
InChIKey: YURJSTAIMNSZAE-HHNZYBFYSA-N
About the compound:

Ginsenoside Rg1 is a ginsenoside found in Panax ginseng and Panaxjaponicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-glucopyranosides, and in which a double bond has been introduced at the 24-25 position. It has a role as a neuroprotective agent and a pro-angiogenic agent. It is a 12beta-hydroxy steroid, a beta-D-glucoside, a tetracyclic triterpenoid, a ginsenoside and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane. Ginsenosides are a class of steroid glycosides, and triterpenesaponins, found exclusively in the plant genus Panax (ginseng). Ginsenosides have been the target of research, as they are viewed as the active compounds behind the claims of ginseng's efficacy. Because ginsenosides appear to affect multiple pathways, their effects are complex and difficult to isolate. Rg1 Appears to be most abundant in Panax ginseng (Chinese/Korean Ginseng). It improves spatial learning and increase hippocampal synaptophysin level in mice, plus demonstrates estrogen-like activity.

GHS Hazard Statements

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

Properties:

Chemical and Physical Properties

Property Name

Property Value

Molecular Weight

801.0 g/mol

XLogP3-AA

2.7

Hydrogen Bond Donor Count

10

Hydrogen Bond Acceptor Count

14

Rotatable Bond Count

10

Exact Mass

800.49220697 g/mol

Monoisotopic Mass

800.49220697 g/mol

Topological Polar Surface Area

239Ų

Heavy Atom Count

56

Formal Charge

0

Complexity

1410

Isotope Atom Count

0

Defined Atom Stereocenter Count

21

Undefined Atom Stereocenter Count

0

Defined Bond Stereocenter Count

0

Undefined Bond Stereocenter Count

0

Covalently-Bonded Unit Count

1

Compound Is Canonicalized

Yes

Source: PubChem           

Source Species: Luffa cylindrica
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