Erythritol

Erythritol
Compound Structure:
Synonyms: (2S,3R)-butane-1,2,3,4-tetrol; (2R,3S)-butane-1,2,3,4-tetrol; (2R,3S)-rel-1,2,3,4-Butanetetrol; 1,2,3,4-Butanetetrol; 1,2,3,4-Butanetetrol, (R*,S*)-; 1,2,3,4-Butanetetrol, (theta,S)-; 1,2,3,4-Butanetetrol, (2R,3S)-rel-; 1,2,3,4-Butanetetrol, (2R,3S)-; 1,3
Compound ID: NMPC-1025
PubChem ID:

222285

Molecular Formula: C4H10O4
Canonical SMILES: C(C(C(CO)O)O)O
InChIKey: UNXHWFMMPAWVPI-ZXZARUISSA-N
About the compound:

Erythritol is an organic compound known as a sugar alcohol, specifically a four-carbon achiral mesopolyol. It exists naturally and is the reduced form of either D- or L-erythrose, as well as one of the two reduced forms of erythrulose. Widely used as a food additive and sugar substitute, erythritol is commercially synthesized from corn through a process involving enzymes and fermentation.In terms of sweetness, erythritol  is about 60–70% as sweet as sucrose (common table sugar). However, it has several notable benefits: erythritol is almost completely noncaloric, meaning it contributes virtually no calories when consumed. Additionally, it does not impact blood sugar levels, making it a more favorable option for individuals monitoring their blood glucose. Another significant advantage of erythritol is that it does not cause tooth decay, a common concern with many traditional sugars. The commercial development of erythritol as a sweetener was pioneered by Japanese companies in the 1990s, leading to its widespread use and recognition in various food products around the world.

GHS Hazard Statements

Not Classified

Reported as not meeting GHS hazard criteria by 150 of 151 companies (only ~ 0.7% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

First Aid

In case of exposure to higher alcohols and related compounds:

Immediate first aid:

Ensure adequate decontamination.

If not breathing, perform artificial respiration using appropriate equipment.

Flush contaminated eyes with gently flowing water.

Do not induce vomiting; if vomiting occurs, position patient to maintain open airway.

Keep patient calm and maintain normal body temperature.

Seek medical attention.

Basic Treatment:

Establish patent airway, suction if necessary.

Administer oxygen, monitor for shock, treat if necessary.

Monitor for pulmonary edema, anticipate seizures, treat if necessary.

For eye contamination, flush with water or saline.

Do not use emetics.

For ingestion, rinse mouth, administer water for dilution if possible, administer activated charcoal.

Advanced Treatment:

Consider intubation for airway control in unconscious or severely distressed patients.

Use positive-pressure ventilation if beneficial.

Monitor cardiac rhythm, treat arrhythmias.

Start IV fluid administration, cautiously if hypovolemic.

Consider vasopressors for hypotension.

Monitor for hypoglycemia, administer dextrose if necessary.

Treat seizures with appropriate medication.

Use proparacaine hydrochloride to assist eye irrigation.

Currance, P.L. Clements, B., Bronstein, A.C. (Eds).; Emergency Care For Hazardous Materials Exposure. 3Rd edition, Elsevier Mosby, St. Louis, MO 2005, p. 233

Properties:

Chemical and Physical Properties

Property Name

Property Value

Molecular Weight

122.12 g/mol

XLogP3

-2.3

Hydrogen Bond Donor Count

4

Hydrogen Bond Acceptor Count

4

Rotatable Bond Count

3

Exact Mass

122.05790880 g/mol

Monoisotopic Mass

122.05790880 g/mol

Topological Polar Surface Area

80.9Ų

Heavy Atom Count

8

Formal Charge

0

Complexity

48

Isotope Atom Count

0

Defined Atom Stereocenter Count

2

Undefined Atom Stereocenter Count

0

Defined Bond Stereocenter Count

0

Undefined Bond Stereocenter Count

0

Covalently-Bonded Unit Count

1

Compound Is Canonicalized

Yes

Physical Description

White, odourless, non-hygroscopic, heat-stable crystals with a sweetness of approximately 60-80 % that of sucrose.

Boiling Point

330.5 °C

Melting Point

119-123 °C

Density

1.451 g/cu cm at 20 °C

Solubility 

Freely soluble in water, slightly soluble in ethanol, insoluble in diethyl ether.

Vapor Pressure

0.0000237 [mmHg]

Source: PubChem       

Source Species: Tragia benthamii
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