Diosmin

Diosmin
Compound Structure:
Synonyms: Diosmin; Barosmin; Diosimin; Venosmine; Diosmil; Flebosten; Diosmine; Daflon; Tovene; Ven-Detrex; Diovenor; Buchu Resin; Litosmil; Veno-V; Flebosmil; Diosminum; Rioven
Compound ID: NMPC-971
PubChem ID:

5281613

Molecular Formula: C28H32O15
Canonical SMILES: CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O
InChIKey: GZSOSUNBTXMUFQ-YFAPSIMESA-N
About the compound:

Diosmin is a disaccharide derivative that consists of diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as an antioxidant and an anti-inflammatory agent. It is a glycosyloxyflavone, a rutinoside, a disaccharide derivative, a monomethoxyflavone and a dihydroxyflavanone. It is functionally related to a diosmetin. Chronic venous insufficiency is a common condition the western population. Compression and pharmacotherapy are frequently used to manage chronic venous insufficiency, improving circulation and symptoms of venous disease. Diosmin is a bioflavonoid isolated from various plants or synthesized from [hesperidin]. It is used for the improvement of capillary fragility or venous insufficiency, including chronic venous insufficiency (CVI) and hemorrhoids. Diosmin is widely available over-the-counter and demonstrates a favourable a favorable safety profile.

GHS Hazard Statements

Not Classified

Reported as not meeting GHS hazard criteria by 89 of 98 companies (only ~ 9.2% companies provided GHS information). For more detailed information, please visit ECHA C&L website.


Properties:

Chemical and Physical Properties

Computed Properties

Property Name

Property Value

Molecular Weight

608.5 g/mol

XLogP3-AA

-0.8

Hydrogen Bond Donor Count

8

Hydrogen Bond Acceptor Count

15

Rotatable Bond Count

7

Exact Mass

608.17412031 g/mol

Monoisotopic Mass

608.17412031 g/mol

Topological Polar Surface Area

234Ų

Heavy Atom Count

43

Formal Charge

0

Complexity

995

Isotope Atom Count

0

Defined Atom Stereocenter Count

10

Undefined Atom Stereocenter Count

0

Defined Bond Stereocenter Count

0

Undefined Bond Stereocenter Count

0

Covalently-Bonded Unit Count

1

Compound Is Canonicalized

Yes

Physical Description

 

Boiling Point

926.8±65.0

Melting Point

277-278

Source: PubChem

Source Species:
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