D-Mannitol

Compound Structure:

Synonyms:

D-mannitol; mannitol; Mannite; Osmitrol; Manna sugar; Cordycepic acid; Osmofundin; Resectisol; Diosmol; Mannit; Mannazucker; Mannidex; Mannigen; Mannistol; Invenex; Isotol; Osmosal; Marine Crystal; Maniton-S; D-(-)-Mannitol; Bronchitol; Mannitol, D-

Compound ID:

NMPC-975

PubChem ID:

6251

Molecular Formula:

C6H14O6

Canonical SMILES:

C(C(C(C(C(CO)O)O)O)O)O

InChIKey:

FBPFZTCFMRRESA-KVTDHHQDSA-N

About the compound:

D-mannitol is the D-enantiomer of mannitol. It has a role as an osmotic diuretic, a sweetening agent, an antiglaucoma drug, a metabolite, an allergen, a hapten, a food bulking agent, a food anticaking agent, a food humectant, a food stabiliser, a food thickening agent, an Escherichia coli metabolite and a member of compatible osmolytes. Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for this indication under the name BRONCHITOL® by Chiesi USA Inc.

GHS Hazard Statements

Not Classified

Reported as not meeting GHS hazard criteria by 1448 of 1448 companies. For more detailed information, please visit ECHA C&L website.

First Aid

In case of exposure:

EYES: Remove contact lenses if present, flush with water or saline for 20-30 minutes, then seek immediate medical attention regardless of symptoms.

SKIN: Flood affected skin with water, wash with soap, and seek medical help if redness or irritation occurs.

INHALATION: Leave contaminated area, breathe fresh air, seek medical help if symptoms develop, and provide respiratory protection.

INGESTION: Do not induce vomiting. Give water if conscious, seek medical advice, and transport to hospital if advised.

Remember: Prompt action and medical attention are crucial in all cases of exposure (NTP, 1992).

National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.

Properties:

Chemical and Physical Properties

Property Name	Property Value
Molecular Weight	182.17 g/mol
XLogP3	-3.1
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	182.07903816 g/mol
Monoisotopic Mass	182.07903816 g/mol
Topological Polar Surface Area	121Å²
Heavy Atom Count	12
Formal Charge	0
Complexity	105
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes
Physical Description	D-mannitol appears as odorless white crystalline powder or free-flowing granules. Sweet taste. (NTP, 1992)
Boiling Point	290-295 °C @ 3.5 mm Hg
Melting Point	168°C
Density	1.489 at 68 °F (NTP, 1992) - Denser than water; will sink
Solubility	1 g in about 5.5 ml water; more sol in hot water; insol in ether; sol in pyridine, aniline; sol in aqsoln of alkalies; 1 g dissolves in 18 ml glycerol (density 1.24); 1 g dissolves in about 83 ml alc

Source: PubChem

Source Species:

Tragia benthamii

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