73170

Alpha-amyrin is a pentacyclic triterpenoid with a chemical structure belonging to the ursane skeleton. It contains a double bond between positions 12 and 13 and has a hydroxy group at the 3beta position. Alpha-amyrin is classified as a secondary alcohol and is derived from a hydride of an ursane. The amyrins, including alpha-amyrin, beta-amyrin (which has an oleanane skeleton), and delta-amyrin, are closely related natural compounds of the triterpene class. They share the chemical formula C30H50O and are commonly found in various plant sources, including epicuticular wax. In plant biosynthesis, alpha-amyrin serves as the precursor for ursolic acid, while beta-amyrin is the precursor for oleanolic acid. These compounds play important roles in the biological activities of plants. Alpha-amyrin has been studied for its pharmacological properties and has been found to exhibit long-lasting antinociceptive (pain-relieving) and anti-inflammatory effects. These effects are attributed to the activation of cannabinoid receptors CB1 and CB2, as well as the inhibition of cytokine production and the expression of NF-κB, CREB, and cyclooxygenase 2. Additionally, alpha-amyrin has been identified in various sources, including dandelion coffee, and its presence contributes to the chemical composition of these natural products.

GHS Hazard Statements

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

Chemical and Physical Properties

Source: PubChem